Links, November 21, 2025

From Lada Nuzhna’s trilly biotech post:

• Advancing gene-editing platforms to improve the viability of rare-disease therapeutics: key insights from a 2024 Scientific Exchange hosted by ARM, ISCT, and Danaher
• First-In-Human Therapy Stem Cell Dopaminergic Progenitor Parkinson’s
• Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment
• Personalized gene editing helped one baby: can it be rolled out widely?

Long history:

• The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it

Repurposing statins for Alzheimer’s:

• Cholesterol and Statins in Alzheimer’s Disease: II. Review of Human Trials and Recommendations
• A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

Clinical trial success rates in different branches of medicine:

• Estimation of clinical trial success rates and related parameters

Bimagrumab in older adults with sarcopenia (JAMA Network Open)

Drugs@FDA Data Files

US-China biotech race:

• The State of the US-China Biotech Race

• A Software Engineer’s Guide to Biotech

• Search BioNumbers - The Database of Useful Biological Numbers

Underlying cause of death: CDC WONDER: Underlying Cause of Death

A Playbook for Human Evidence